protein

Fractalkine/CX3CL1 Protein, Rat

HY-P79193

5 μg;10 μg;50 μg;100 μg

95;160;450;765 USD

Fractalkine/CX3CL1 Protein, Rat

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

95;160;450;765 USD

Fractalkine/CX3CL1 protein is a versatile chemokine that acts as a ligand for CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. It regulates immune response, inflammation, adhesion, and chemotaxis. It activates integrins via CX3CR1-dependent and -independent pathways, binding to site 1 with CX3CR1 and site 2 without CX3CR1. Soluble Fractalkine/CX3CL1 attracts T-cells and monocytes, not neutrophils. Fractalkine/CX3CL1 Protein, Rat is the recombinant rat-derived Fractalkine/CX3CL1 protein, expressed by E. coli , with tag free. The total length of Fractalkine/CX3CL1 Protein, Rat is 79 a.a., with molecular weight of ~11 kDa.

Rat

Fractalkine/CX3CL1 protein serves as a multifaceted chemokine, acting as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling cascade exhibits diverse functions across various tissue compartments, encompassing roles in immune response modulation, inflammation regulation, cell adhesion, and chemotaxis. Specifically, it plays a crucial role in regulating leukocyte adhesion and migration processes at the endothelium. Fractalkine/CX3CL1 demonstrates the ability to activate integrins in a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, it activates integrins by binding to the classical ligand-binding site (site 1) in integrins. Conversely, in the absence of CX3CR1, it binds to a distinct site (site 2) on integrins, enhancing the binding of other integrin ligands to site 1. The soluble form of Fractalkine/CX3CL1 exhibits chemotactic properties for T-cells and monocytes, though not for neutrophils.

Fractalkine; Cx3cl1; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; Acc1; Fkn; Scyd1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.8.

Room temperature in continental US; may vary elsewhere.