protein

Stabilin-2 Protein, Human (His)

HY-P79135

5 μg;10 μg;50 μg;100 μg

100;160;450;720 USD

Stabilin-2 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

100;160;450;720 USD

Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

Human

Stabilin-2 Protein serves as a multifunctional phosphatidylserine receptor, facilitating the engulfment of apoptotic cells, and functions as a hyaluronan receptor, mediating the endocytosis of hyaluronic acid (HA). Additionally, it acts as a primary systemic scavenger receptor, binding to various ligands such as heparin, chondroitin sulfate, dermatan sulfate, non-glycosaminoglycan molecules, acetylated low-density lipoprotein, pro-collagen propeptides, and advanced glycation end products. Stabilin-2 may play a crucial role in maintaining tissue integrity through support for extracellular matrix turnover and contribute to the fluidity of bodily liquids by resorbing hyaluronan. This receptor also functions as a counter receptor, facilitating lymphocyte recruitment in the hepatic vasculature, and displays the ability to bind Gram-positive and Gram-negative bacteria, potentially playing a role in defense against bacterial infection. The proteolytically processed 190 kDa form of Stabilin-2 serves as an endocytosis receptor for heparin internalization, hyaluronan, and chondroitin sulfate. Interactions with GULP1, heparin, alpha-M/beta-2 integrin, and thymosin beta 4 further underscore the diverse functions of Stabilin-2.

Stabilin-2; STAB2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; Hyaluronan receptor for endocytosis; FEEL2; FELL; FEX2; HARE

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.