protein

Norrin Protein, Human

HY-P79124

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

135;215;600;960;2680;4280 USD

Norrin Protein, Human

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

135;215;600;960;2680;4280 USD

Norrin protein activates canonical Wnt signaling by binding to FZD4 and LRP5, promotes retinal vascularization and stabilizes β-catenin (CTNNB1). It cooperates with TSPAN12 to independently activate FZD4, suggesting a Wnt-independent mechanism. Norrin Protein, Human is the recombinant human-derived Norrin protein, expressed by E. coli , with tag free. The total length of Norrin Protein, Human is 109 a.a., with molecular weight of ~13 kDa.

Human

Norrin Protein, as a vital player in the canonical Wnt signaling pathway, activates this pathway by engaging the FZD4 and LRP5 coreceptor complex. Its significance lies in its central role in retinal vascularization, as it acts as a ligand for FZD4, resulting in the stabilization of beta-catenin (CTNNB1) and the activation of LEF/TCF-mediated transcriptional programs. Additionally, Norrin Protein collaborates with TSPAN12 to independently activate FZD4, suggesting the existence of a Wnt-independent signaling mechanism that also contributes to the accumulation of beta-catenin (CTNNB1). Furthermore, Norrin Protein may participate in a pathway that regulates neural cell differentiation and proliferation, and it potentially plays a role in neuroectodermal cell-cell interactions. It forms homodimers through disulfide linkages and is part of a complex consisting of TSPAN12, FZD4, LRP5/6, and norrin itself (NDP). Notably, Norrin Protein exhibits a high affinity for binding to FZD4 and interacts with LRP6, specifically with its Beta-propellers 1 and 2.

Norrin; NDP; Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein; EVR2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 4 mM HCL, pH 2.5.

Room temperature in continental US; may vary elsewhere.