protein

Frizzled-9 Protein, Mouse (HEK293, mFc)

HY-P79115

5 μg;10 μg

80;135 USD

Frizzled-9 Protein, Mouse (HEK293, mFc)

proteins

HEK293

5 μg;10 μg

80;135 USD

Frizzled-9 is a WNT2 receptor that is critical for activation of the β-catenin pathway, involved in Disheveled protein activation, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. In addition to classical signaling, it negatively regulates acetylcholine receptor clustering in neuromuscular junction assembly and affects the viability of neural progenitor cells by regulating the cell cycle. Frizzled-9 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Frizzled-9 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Frizzled-9 Protein, Mouse (HEK293, mFc) is 163 a.a., with molecular weight of 52-61 kDa.

Mouse

Frizzled-9, serving as the receptor for WNT2, is a crucial player in the beta-catenin canonical signaling pathway, orchestrating the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and subsequent activation of Wnt target genes. Beyond its role in canonical Wnt signaling, Frizzled-9 exhibits multifaceted functions. It contributes to neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin pathway. In neural progenitor cells (NPCs), Frizzled-9 influences cell viability by negatively regulating cell cycle arrest, thereby inhibiting the apoptotic process. The receptor's involvement in hippocampal development includes the regulation of neuroblast proliferation and apoptotic cell death. Moreover, Frizzled-9 plays a pivotal role in bone dynamics, modulating bone formation through non-canonical Wnt signaling mediated via ISG15 and positively impacting bone regeneration through non-canonical Wnt signaling pathways.

Frizzled-9; Fzd9; Fz-9; mFz3; mFz9; CD349; Fzd3

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.