product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
IL-6 Protein, Equine
catalog :
HY-P79101
quantity :
5 μg;10 μg;50 μg;100 μg;500 μg;1 mg
price :
110;180;500;800;2240;3500 USD
more info or order :
product information
Catalog Number :
HY-P79101
Product Name :
IL-6 Protein, Equine
Product Type :
proteins
Host Species :
E. coli
Size :
5 μg;10 μg;50 μg;100 μg;500 μg;1 mg
List Price :
110;180;500;800;2240;3500 USD
Product Description :
IL-6 protein is a crucial cytokine in immunity, tissue regeneration and metabolism. It binds to IL6R and forms a complex that binds to IL6ST/gp130, triggering intracellular IL6 signaling. Membrane-bound IL6:IL6R complexes induce "cluster signaling" that activates IL6ST receptors on neighboring cells. IL-6 Protein, Equine is the recombinant equine-derived IL-6 protein, expressed by E. coli , with tag free.
SpeciesSummary :
Equine
Background :
IL-6, a multifunctional cytokine, exerts diverse biological effects in immunity, tissue regeneration, and metabolism. Upon binding to its receptor, IL6R, the complex associates with the signaling subunit IL6ST/gp130, initiating the intracellular IL6-signaling pathway. This interaction can elicit 'classic signaling' when IL6 binds to membrane-bound IL6R, or 'trans-signaling' when IL6 and soluble IL6R engage IL6ST. Additionally, 'cluster signaling' occurs when IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. IL-6 is a crucial inducer of the acute phase response, rapidly produced during infection and tissue injury for host defense. However, excessive IL-6 synthesis is implicated in various disease pathologies. In the innate immune response, myeloid cells, including macrophages and dendritic cells, synthesize IL-6 upon recognizing pathogens through toll-like receptors (TLRs) at infection sites or tissue injuries. In the adaptive immune response, IL-6 is essential for B cell differentiation into immunoglobulin-secreting cells, T follicular helper (Tfh) cell development, and driving naive CD4(+) T cells toward the Th17 lineage. Furthermore, IL-6 plays a significant role in myeloma cell proliferation and the survival of plasmablast cells.
ALTnames :
IL6; Interleukin-6; BSF2; HSF; IFNB2; Interleukin 6
Purity :
Greater than 95% as determined by reducing SDS-PAGE
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 6.5, 8% trehalose.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA