product summary
Loading...
company name :
MedChem Express LLC
product type :
protein
product name :
IL-6 Protein, Canine
catalog :
HY-P79088
quantity :
5 μg;10 μg;50 μg;100 μg
price :
68;110;310;500 USD
more info or order :
product information
Catalog Number :
HY-P79088
Product Name :
IL-6 Protein, Canine
Product Type :
proteins
Host Species :
E. coli
Size :
5 μg;10 μg;50 μg;100 μg
List Price :
68;110;310;500 USD
Product Description :
IL-6 is a multifunctional cytokine that binds to IL6R and forms a complex with IL6ST/gp130 to initiate intracellular signaling. It induces "classical signaling" and "trans signaling" by interacting with membrane-bound IL6R or soluble IL6R. IL-6 Protein, Canine is the recombinant canine-derived IL-6 protein, expressed by E. coli , with tag free.
SpeciesSummary :
Canine
Background :
IL-6 protein, a versatile cytokine, exerts a wide range of biological functions in immunity, tissue regeneration, and metabolism. Upon binding to its receptor IL6R, the complex associates with the signaling subunit IL6ST/gp130, initiating the intracellular IL-6 signaling pathway. The interaction between membrane-bound IL6R and IL6ST triggers 'classic signaling,' while the binding of IL-6 and soluble IL6R to IL6ST stimulates 'trans-signaling.' Additionally, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. IL-6 is a potent inducer of the acute phase response, contributing to host defense during infection and tissue injury; however, excessive IL-6 synthesis is implicated in disease pathology. In the innate immune response, myeloid cells such as macrophages and dendritic cells synthesize IL-6 upon recognizing pathogens through toll-like receptors (TLRs) at the infection or injury site. Furthermore, IL-6 is crucial in the adaptive immune response, essential for B cell differentiation into immunoglobulin-secreting cells and playing a major role in the differentiation of CD4(+) T cell subsets, including the development of T follicular helper (Tfh) cells needed for germinal-center formation and driving naive CD4(+) T cells to the Th17 lineage. IL-6 also proves necessary for myeloma cell proliferation and the survival of plasmablast cells.
ALTnames :
Interleukin-6; Interleukin 6; IL-6
Purity :
Greater than 95% as determined by reducing SDS-PAGE
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 5% trehalose.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA