protein

GBP4 protein, Mouse (HEK293, His)

HY-P790016

50 μg

950 USD

GBP4 protein, Mouse (HEK293, His)

proteins

HEK293

50 μg

950 USD

GBP4, an IFN-inducible GTPase, crucially defends against various pathogens.It hydrolyzes GTP to GDP and aids inflammasome assembly by releasing ligands from bacteria.GBP4 promotes pathogen-containing vacuole lysis, facilitating cytosolic entry, where it recruits proteins like Gm12250/Irgb10 for bacterial cytolysis.This liberation activates inflammasomes, including CASP4/CASP11 and AIM2.GBP4 may also influence erythroid differentiation.GBP4 protein, mouse (HEK293, His) is the recombinant mouse-derived GBP4 protein, expressed by HEK293 , with N-8*His labeled tag.

Mouse

GBP4 is an interferon (IFN)-inducible GTPase with crucial roles in innate immunity against a broad spectrum of bacterial, viral, and protozoan pathogens. It efficiently hydrolyzes GTP, predominantly yielding GDP. Upon infection, GBP4 is recruited to pathogen-containing vacuoles or vacuole-escaped bacteria, acting as a positive regulator of inflammasome assembly. This occurs by promoting the release of inflammasome ligands from bacteria. GBP4 facilitates pathogen-containing vacuole lysis, leading to the release of pathogens into the cytosol. In the cytosol, it promotes the recruitment of proteins, such as Gm12250/Irgb10, which mediate bacterial cytolysis. This liberation of ligands, including lipopolysaccharide (LPS) and double-stranded DNA (dsDNA), activates inflammasomes, such as the non-canonical CASP4/CASP11 inflammasome and AIM2 inflammasome, respectively. Additionally, GBP4 may play a role in erythroid differentiation.

GBP4; guanylate binding protein 4; guanylate-binding protein 4; Mpa2; GBP-4; GTP-binding protein 4; guanine nucleotide-binding protein 4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.