protein

Aminopeptidase N/APN Protein, Human (HEK293, His, solution)

HY-P7899

10 μg;50 μg

235;705 USD

Aminopeptidase N/APN Protein, Human (HEK293, His, solution)

proteins

HEK293

10 μg;50 μg

235;705 USD

Aminopeptidase N/APN Protein, Human (HEK 293, His) is a recombinant aminopeptidase N/APN protein with a His tag. APN (also known as CD13) is a Zn 2+ dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid [1] .

Human

Aminopeptidase N (APN, CD13) is a zinc-dependent ectopeptidase of the M1 family. It is a type II integral membrane protein and is located on the surface of many mammalian cells like fibroblasts, epithelial and myeloid cells. APN consists of 967 amino acids (aa), which can be divided into three regions. A short N-terminal region is located in the cytoplasm (aa 1–9), followed by a single-helix transmembrane domain (aa 10–27) and a large extracellular region (aa 28–967). APN is involved in multiple processes. It is most widely known for its protease activity in the renin-angiotensin system, where it proteolytically converts angiotensin III to IV. In addition to its enzymatic activity, it functions as a receptor for coronaviruses and has been proposed to participate in the endocytosis of cholesterol. Some of the functions of APN are mediated by protein-protein interactions [2] .

rHuAminopeptidase N/APN Protein, His; Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD13 antigen; CD13; CD13APN; PEPN; PEPNhAPN

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.

Shipping with dry ice.