protein

Creatine kinase B-type/CKB Protein, Human (His)

HY-P7897

10 μg;50 μg

55;165 USD

Creatine kinase B-type/CKB Protein, Human (His)

proteins

E. coli

10 μg;50 μg

55;165 USD

Creatine kinaseB-type/CKB Protein, Human (His) is the most abundant creatine kinase isoenzyme in purified brown adipocytes. CKB reversibly catalyzes the transfer of phosphate between ATP and various phosphogens.

Human

Creatine kinase B (CKB) is indispensable for thermogenesis resulting from the futile creatine cycle, during which it traffics to mitochondria using an internal mitochondrial targeting sequence. CKB is powerfully induced by thermogenic stimuli in both mouse and human adipocytes. Adipocyte-selective inactivation of Ckb in mice diminishes thermogenic capacity, increases predisposition to obesity, and disrupts glucose homeostasis. CKB is therefore a key effector of the futile creatine cycle [1] .

rHuCreatine kinase B-type/CKB , His; B-CK; CKB; Creatine Kinase BB

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 7.5.

Shipping with dry ice