protein

CD20/MS4A1 Protein, Human (Trx-His, Solution)

HY-P7896

10 μg

125 USD

CD20/MS4A1 Protein, Human (Trx-His, Solution)

proteins

E. coli

10 μg

125 USD

CD20/MS4A-1 Protein,Human (Trx-His) is an integral membrane protein expressed during B lymphocyte development.

Human

CD20 is an non-glycosylated protein expressed on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. Human cluster of differentiation 20 (CD20) is an integral membrane protein expressed during B lymphocyte development. CD20 it is involved in intracellular calcium signaling associated with the B cell receptor. CD20 is also expressed in malignant B cells and is the target of approved therapeutic monoclonal antibodies (mAbs), which are divided into two groups, type I and type II, on the basis of two signature differences: Type I mAbs recruit complement more potently than type II mAbs and therefore induce robust complement-dependent cytotoxicity (CDC); type I mAbs bind twice as many type II mAbs to a given B cell type [1] [2] .

rHuB-lymphocyte antigen CD20/CD20, Trx-His; MS4A1; CD20; MS4A-1; B1; Bp35; CVID5; LEU-16; MS4A2; S7

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, pH 8.0.

Shipping with dry ice