protein

CD19 Protein, Human (Biotinylated, Fc)

HY-P78917

5 μg;10 μg;50 μg;100 μg

110;185;520;850 USD

CD19 Protein, Human (Biotinylated, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

110;185;520;850 USD

The CD19 protein is a B cell antigen receptor coreceptor that enhances downstream signaling pathways, lowers the activation threshold, and helps B cells respond to antigens. It activates phosphatidylinositol 3-kinase and mobilizes intracellular Ca(2+). CD19 Protein, Human (Biotinylated, Fc) is the recombinant human-derived CD19 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of CD19 Protein, Human (Biotinylated, Fc) is 272 a.a., with molecular weight of 60-90 kDa.

Human

The CD19 Protein serves as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes, playing a pivotal role in decreasing the threshold for activation of downstream signaling pathways and facilitating B-cell responses to antigens. It activates signaling pathways leading to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Although not required for early steps during B cell differentiation in the blood marrow, CD19 is essential for the normal differentiation of B-1 cells. Moreover, it is crucial for normal B cell differentiation and proliferation in response to antigen challenges, influencing serum immunoglobulin levels and the production of high-affinity antibodies in response to antigen challenge. CD19 forms complexes with CR2/CD21, CD81, and IFITM1/CD225 in the membrane of mature B-cells. It interacts directly with CD81, a crucial interaction for trafficking and compartmentalization of the CD19 receptor on the cell surface of activated B cells. Additionally, CD19 interacts with VAV, GRB2, SOS, PLCG2, LYN, and the regulatory p85 subunit of phosphatidylinositol 3-kinase when phosphorylated on specific tyrosine residues.

CD19; B4; CVID3; MGC12802

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.