protein

LILRB1/CD85j/ILT2 Protein, Human (Biotinylated, HEK293, Fc-Avi)

HY-P78900

5 μg;10 μg;50 μg

100;170;480 USD

LILRB1/CD85j/ILT2 Protein, Human (Biotinylated, HEK293, Fc-Avi)

Protein

HEK293

5 μg;10 μg;50 μg

100;170;480 USD

LILRB1/CD85j/ILT2 Protein is an inhibitory receptor broadly expressed on leukocytes. LILRB1 recognises a wide range of classical HLA-class I allelic variants, as well as the non-classical molecules HLA-F and -G by binding to the conserved a3 domain. LILRB1 also recognises the human CMV-encoded MHC class I homologue UL18. LILRB1 is encoded within the leukocyte receptor complex on 19q13.4. LILRB1 can function as a negative regulator of BiTE molecule-induced tumor cell killing. LILRB1 acts as a novel checkpoint inhibitory molecule capable of restricting BiTE molecule-mediated CD8+ T cell effector function. LILRB1/CD85j/ILT2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived LILRB1/CD85j/ILT2 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.