protein

Collagen alpha-1(III) chain/COL3A Protein, Mouse (HEK293, His)

HY-P7886

10 μg;50 μg

165;496 USD

Collagen alpha-1(III) chain/COL3A Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

165;496 USD

COL3A protein, also known as collagen α-1(III) chain, is an important component of type III collagen and is widely distributed along with type I collagen in most soft connective tissues. In addition to its structural role, COL3A is also involved in the regulation of cortical development. Collagen alpha-1 (III) chain/COL3A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Collagen alpha-1(III) chain/COL3A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Collagen alpha-1 (III) chain/COL3A Protein, Mouse (HEK293, His) is 1065 a.a., with molecular weight of ~130.0 kDa.

Mouse

Collagen alpha-1(III) chain, encoded by the COL3A gene, is a vital constituent of collagen type III, prominently found in various soft connective tissues alongside type I collagen. This protein assumes a crucial role in the intricate regulation of cortical development. Particularly noteworthy is its role as the principal ligand for ADGRG1 in the developing brain. The binding of Collagen alpha-1(III) chain to ADGRG1 has profound effects, including the inhibition of neuronal migration and activation of the RhoA pathway. This activation is achieved by facilitating the coupling of ADGRG1 to GNA13 and possibly GNA12. The trimeric structure of Collagen alpha-1(III) chain consists of identical alpha 1(III) chains, connected through interchain disulfide bonds, and further stabilized by cross-linking through hydroxylysines. This intricate interplay highlights the multifaceted involvement of Collagen alpha-1(III) chain in developmental processes, particularly within the context of neuronal regulation. (

rMuCollagen alpha-1(III) chain/COL3A, His; Collagen alpha-1(III) chain; Col3a1

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.5.

Shipping with dry ice.