protein

CD2 Protein, Human (HEK293, His)

HY-P7882

10 μg;50 μg

165;496 USD

CD2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

165;496 USD

CD2 Protein, Human (HEK 293, His) is a transmembrane cell surface glycoprotein found on virtually all T cells, thymocytes, and NK cells. CD2 ligation by CD58 has been shown to mediate T cell adhesion, T cell activation, T cell cytokine production and T cell and NK cells cytotoxic activity.

Human

The human CD2 molecule is a transmembrane cell surface glycoprotein found on virtually all T cells, thymocytes, and NK cells. CD2 promotes the physical interaction of T-NK lineage cells with antigen-presenting cells (APCs), stromal elements, and a variety of target cells bearing the ubiquitously expressed CD2 ligand, CD58. In the case of T cells, CD2 fosters the initial stages of cell contact even prior to T cell receptor (TCR) recognition of a peptide antigen bound to a major histocompatibility complex (MHC) molecule (pMHC). Thus, unlike with integrin-based adhesion such as that mediated by CD11a/CD18 (LFA-1), CD2 adhesion function is independent of TCR triggering [1] .

rHuT-cell surface antigen CD2/LFA-3 receptor, His; T-cell surface antigen CD2; Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.