protein

LIV-1/SLC39A6 Protein, Human (HEK293, His)

HY-P78749

5 μg;10 μg;50 μg

49;84;235 USD

LIV-1/SLC39A6 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

49;84;235 USD

LIV-1/SLC39A6 is a zinc influx transporter that regulates zinc homeostasis and induces epithelial-mesenchymal transition (EMT).Used in conjunction with SLC39A10, it can promote cellular zinc absorption and trigger EMT.LIV-1/SLC39A6 Protein, Human (HEK293, His) is the recombinant human-derived LIV-1/SLC39A6 protein, expressed by HEK293 , with C-His labeled tag.

Human

LIV-1/SLC39A6, a zinc-influx transporter, intricately regulates zinc homeostasis and contributes to the induction of epithelial-to-mesenchymal transition (EMT). Functionally, when forming a heterodimer with SLC39A10, this complex mediates cellular zinc uptake, serving as a pivotal trigger for EMT. The SLC39A10-SLC39A6 heterodimer not only controls NCAM1 phosphorylation but also influences its integration into focal adhesion complexes during EMT. The zinc influx facilitated by this heterodimeric complex plays a crucial role in inactivating GSK3B, leading to nuclear accumulation of unphosphorylated SNAI1, which subsequently down-regulates adherence genes like CDH1, thereby promoting loss of cell adherence. Beyond its involvement in EMT, the SLC39A10-SLC39A6 heterodimer plays a fundamental role in initiating mitosis by importing zinc into cells, triggering a pathway that culminates in the onset of mitosis. Additionally, this transporter complex contributes to T-cell receptor signaling regulation and facilitates proper zinc influx for meiotic progression during the oocyte-to-egg transition.

SLC39A6; LIV-1; ZIP6; Zinc transporter ZIP6; ZIP-6

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.