protein

Furin/PCSK3 Protein, Human (HEK293, His)

HY-P78747

5 μg;10 μg;50 μg;100 μg

106;180;505;850 USD

Furin/PCSK3 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

106;180;505;850 USD

Furin/PCSK3 protein is a ubiquitous endoprotease in the constitutive secretory pathway that efficiently cleaves the RX(K/R)R consensus motif. Its versatility is evident in processing TGFB1 (essential for TGF-β-1 activation) and converting the brain natriuretic factor prohormone into active BNP(1-32). Furin/PCSK3 Protein, Human (HEK293, His) is the recombinant human-derived Furin/PCSK3 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of Furin/PCSK3 Protein, Human (HEK293, His) is 548 a.a., with molecular weight of 60-75 kDa.

Human

Furin/PCSK3 protein is a ubiquitous endoprotease found within constitutive secretory pathways, exhibiting a remarkable ability to cleave at the RX(K/R)R consensus motif. This enzymatic versatility is evidenced by its involvement in the processing of TGFB1, a crucial step in the activation of TGF-beta-1. Furin/PCSK3 also plays a pivotal role in the conversion of the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). Furthermore, by mediating the processing of the accessory subunit ATP6AP1/Ac45 of the V-ATPase, Furin/PCSK3 contributes to the regulation of acidic environments within dense-core secretory granules in islets of Langerhans cells. Notably, in the context of microbial infection, this protease is implicated in the cleavage and activation of diphtheria toxin DT.

FURIN; FUR; PACE; PCSK3; SPC1

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0, 20% Glycerol.

Shipping with dry ice