protein

FZD2 Protein, Human (HEK293, Fc)

HY-P78722

5 μg;10 μg;50 μg

40;70;200 USD

FZD2 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

40;70;200 USD

FZD2 protein is a receptor for Wnt proteins that activates the β-catenin classical pathway, inhibits GSK-3 kinase and triggers Wnt target genes. FZD2 and some family members possess a secondary PKC-calcium pathway, but its integration with the classical pathway remains unclear. FZD2 Protein, Human (HEK293, Fc) is the recombinant human-derived FZD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FZD2 Protein, Human (HEK293, Fc) is 167 a.a., with molecular weight of 50-62 kDa.

Human

FZD2 Protein functions as a receptor for Wnt proteins, typically engaging the beta-catenin canonical signaling pathway, leading to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and subsequent activation of Wnt target genes. Some family members, including FZD2, have demonstrated a secondary signaling pathway involving PKC and calcium fluxes, the integration of which with the canonical pathway remains to be fully elucidated, as PKC appears essential for Wnt-mediated inactivation of GSK-3 kinase. These pathways likely involve interactions with G-proteins and may play roles in transduction and intercellular transmission of polarity information during tissue morphogenesis and in differentiated tissues. Notably, FZD2 acts as a receptor for C.difficile toxin TcdB in the colonic epithelium, where TcdB binding occupies the Wnt-adducted palmitoleate binding site in frizzled receptors, preventing Wnt binding and downstream Wnt signaling.

FZD2; Frizzled-2; Fz-2; hFz2; FzE2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.