protein

ENPP-3 Protein, Mouse (HEK293, His)

HY-P78705

5 μg;10 μg;50 μg;100 μg

40;70;190;320 USD

ENPP-3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

40;70;190;320 USD

ENPP-3 is a hydrolase that metabolizes extracellular nucleotides (ATP, GTP, UTP, CTP), which is critical for immune regulation of inflammation and chronic allergic reactions. By eliminating extracellular ATP, ENPP-3 inhibits basophil and mast cell activation and suppresses the release of inflammatory cytokines. ENPP-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ENPP-3 protein, expressed by HEK293 , with N-10*His labeled tag.

Mouse

ENPP-3, a hydrolase, exhibits the ability to metabolize various extracellular nucleotides, including ATP, GTP, UTP, and CTP. This enzymatic activity plays a crucial role in modulating immune responses, particularly during inflammation and the chronic phases of allergic reactions. ENPP-3 acts by eliminating extracellular ATP, a signaling molecule that activates basophils and mast cells, leading to the release of inflammatory cytokines. Moreover, in the lumen of the small intestine, ENPP-3 metabolizes extracellular ATP, thereby preventing ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Besides its involvement in nucleotide metabolism, ENPP-3 also exhibits alkaline phosphodiesterase activity, adding to its multifaceted role in cellular processes.

ENPP3; CD203c; NPP3; E-NPP3; PD-Ibeta; NPPase; PDNP3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized a 0.22 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 7.5.

Room temperature in continental US; may vary elsewhere.