protein

LBP Protein, Human (I465F, HEK293, His)

HY-P78664

5 μg;10 μg;50 μg

40;65;180 USD

LBP Protein, Human (I465F, HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

40;65;180 USD

LBP proteins play a central role in the innate immune response by directly binding to the lipid A moiety of bacterial lipopolysaccharide (LPS). This interaction enhances CD14 affinity, promotes its binding to LPS, and promotes cytokine release in response to bacterial lipopolysaccharide. LBP Protein, Human (I465F, HEK293, His) is the recombinant human-derived LBP protein, expressed by HEK293 , with C-10*His labeled tag and I465F, , , , mutation. The total length of LBP Protein, Human (I465F, HEK293, His) is 456 a.a., with molecular weight of 65-75 kDa.

Human

LBP takes center stage in the innate immune response by directly engaging with the lipid A moiety of bacterial lipopolysaccharides (LPS), a pivotal glycolipid abundantly present in the outer membrane of Gram-negative bacteria. This interaction serves as a critical affinity enhancer for CD14, promoting its association with LPS and facilitating the subsequent release of cytokines in response to bacterial lipopolysaccharide. Notably, LBP, when bound to LPS, establishes interactions through its C-terminus with both soluble and membrane-bound CD14, underscoring its instrumental role in orchestrating key events in the innate immune system's defense against bacterial pathogens.

Lipopolysaccharide-binding protein; LBP

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.