protein

Cystatin C/CST3 Protein, Human (HEK293, His)

HY-P7865

5 μg;10 μg;50 μg;100 μg

95;165;496;845 USD

Cystatin C/CST3 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

95;165;496;845 USD

Cystatin C/CST3 protein can significantly inhibit cysteine proteases and locally regulate their enzymatic activity. It captures and binds free plasma hemoglobin, preventing kidney damage and supporting hepatic heme iron recycling. Cystatin C/CST3 Protein, Human (HEK293, His) is the recombinant human-derived Cystatin C/CST3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cystatin C/CST3 Protein, Human (HEK293, His) is 120 a.a., with molecular weight of 15-18 kDa.

Human

The Cystatin C/CST3 protein serves a crucial physiological role as an inhibitor of cysteine proteinases, acting as a local regulator of their enzyme activity. It is known to capture and bind free plasma hemoglobin, preventing kidney damage and enabling the hepatic recycling of heme iron. In cases of hemolysis, where hemoglobin can accumulate in the kidneys and be secreted in urine, Cystatin C/CST3 plays a vital role in clearing the complexes formed between hemoglobin and Haptoglobin. Additionally, Cystatin C/CST3 acts as an antioxidant, exhibits antibacterial activity, and contributes to modulating various aspects of the acute phase response. The protein's homodimeric structure further enhances its functionality and effectiveness as an enzyme inhibitor.

rHuCystatin-C/CST3, His; Cystatin-C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin; CST3

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 500 mM NaCl, 0.01% Tween 80, 1 mM EDTA, 50% Glycerol, pH 8.0 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.