protein

Complement Factor D/Adipsin Protein, Human (HEK293, His)

HY-P7861

10 μg;50 μg

150;430 USD

Complement Factor D/Adipsin Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

150;430 USD

Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~28.0 kDa.

Human

Complement Factor D, also known as Adipsin, is a crucial component in the alternate pathway of the complement system. Functioning analogously to C1s in the classical pathway, Factor D plays a pivotal role in the activation of the C3 convertase. Specifically, Factor D cleaves Factor B when the latter is complexed with Factor C3b. This enzymatic activity leads to the generation of the active C3bbb complex, which serves as the C3 convertase in the alternate pathway. The homologous function of Factor D to C1s underscores its significance in initiating the complement cascade, highlighting its role in immune responses.

rHuComplement Factor D/Adipsin, His; Complement factor D; CFD; Adipsin; C3 convertase activator; Properdin factor D; DF; PFD

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

Room temperature in continental US; may vary elsewhere.