protein

IL-15R alpha & IL-15 Protein, Mouse (HEK293, His)

HY-P78558

5 μg;10 μg;20 μg;50 μg

85;142;210;400 USD

IL-15R alpha & IL-15 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg

85;142;210;400 USD

IL-15R alpha Protein, the high-affinity receptor for interleukin-15, crucially signals in cis and trans, presenting IL-15 to neighboring IL2RG-expressing cells. In neutrophils, it activates SYK kinase, essential for IL-15-induced phagocytosis in a SYK-dependent manner. IL-15R alpha forms a heterotrimer with IL2RB and IL2RG, capable of self-association. Interactions with SYK underscore its intricate involvement in cellular signaling pathways. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-15R alpha & IL-15 protein, expressed by HEK293 , with C-His labeled tag. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His), has molecular weight of ~36 kDa.

Mouse

IL-15R alpha Protein emerges as the high-affinity receptor for interleukin-15, playing a crucial role in cellular signaling. This receptor exhibits the ability to signal both in cis and trans, where IL15R from one subset of cells presents interleukin-15 to neighboring IL2RG-expressing cells. In neutrophils, IL-15R alpha binds and activates the kinase SYK in response to interleukin-15 stimulation, and it is essential for IL-15-induced phagocytosis in a SYK-dependent manner. The interleukin-15 receptor, IL15R, forms a heterotrimer consisting of IL15RA, IL2RB, and IL2RG, with IL15RA capable of self-association (By similarity). Additionally, IL-15R alpha interacts with SYK, further highlighting its intricate involvement in cellular signaling pathways (By similarity).

IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice