protein

CD40L/CD154/TRAP Trimer Protein, Human (HEK293, His-Flag)

HY-P78425

20 μg;50 μg;100 μg

160;300;490 USD

CD40L/CD154/TRAP Trimer Protein, Human (HEK293, His-Flag)

Protein

Human

20 μg;50 μg;100 μg

160;300;490 USD

CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in human, cleaved into 2 chains of membrane form (1-261 a.a.) and soluble form (113-261 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Trimer Protein, Human (HEK293, His-Flag)  is composed of a full-length monomer of 149 amino acids (M113-L261), is expressed in HEK392 cells with N-terminal His- and Flag-tag.