protein

Delta-like protein 1/DLL1 Protein, Human (HEK293, His)

HY-P7841

10 μg;50 μg

100;300 USD

Delta-like protein 1/DLL1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

100;300 USD

DLL1 protein is a transmembrane ligand for NOTCH1, NOTCH2 and NOTCH3 receptors and participates in cis- and trans-interactions. Trans interactions trigger mechanical forces involving clathrin-mediated endocytosis, ligand ubiquitination, EPN1 interactions, and actin polymerization. Delta-like protein 1/DLL1 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

Delta-like protein 1 (DLL1) functions as a transmembrane ligand protein for NOTCH1, NOTCH2, and NOTCH3 receptors, engaging in both cis and trans interactions with the extracellular domain (ECD) of Notch receptors. Upon transinteraction, ligand cells exert mechanical force through clathrin-mediated endocytosis, involving ligand ubiquitination, EPN1 interaction, and actin polymerization. These events facilitate Notch receptor extracellular domain (NECD) transendocytosis, triggering Notch signaling, including cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD). DLL1 is vital for embryonic development, maintaining adult stem cells in various tissues and the immune system. Its involvement in intercellular communication regulates cell lineage, patterning, and morphogenesis, influencing differentiation and proliferation. In brain development, DLL1 plays a role in neuronal differentiation and neocortex development, while in cerebellar development, it regulates Bergmann glial monolayer formation. It also contributes to immune system development, muscle development, pancreatic cell development, arterial identity maintenance, angiogenesis, goblet cell differentiation, inner ear development, and nephron development through the Notch signaling pathway. DLL1 functions as a homodimer and interacts with various proteins, orchestrating a diverse array of cellular processes.

rHuDelta-like protein 1/DLL1, His; Delta-like protein 1; Drosophila Delta homolog 1; Delta1; H-Delta-1; DLL1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Hepes, 150 mM NaCl, 1 mM EDTA, pH 7.4.

Room temperature in continental US; may vary elsewhere.