CD300a/LMIR1 Protein, Mouse (HEK293, His) | MedChem Express LLC HY-P78266 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

CD300a/LMIR1 Protein, Mouse (HEK293, His)

catalog :

HY-P78266

quantity :

20 μg;50 μg;100 μg

price :

155;280;450 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P78266

Product Name :

CD300a/LMIR1 Protein, Mouse (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

20 μg;50 μg;100 μg

List Price :

155;280;450 USD

Product Description :

CD300a/LMIR1 protein inhibits cytolytic activity in NK cells and mast cell degranulation. It negatively regulates TLR signaling via MYD88 and PTPN6 activation, but not TRIF. CD300a/LMIR1 interacts with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D upon tyrosine phosphorylation. CD300a/LMIR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-His labeled tag.

SpeciesSummary :

Mouse

Background :

CD300a/LMIR1 protein serves as an inhibitory receptor that potentially contributes to the down-regulation of cytolytic activity in natural killer (NK) cells and the attenuation of mast cell degranulation. Additionally, it plays a negative regulatory role in Toll-like receptor (TLR) signaling, specifically mediated by MYD88 but not TRIF, by activating PTPN6. Upon tyrosine phosphorylation, CD300a/LMIR1 interacts with PTN6/SHP-1 and PTPN11/SHP-2, along with INPP5D.

ALTnames :

CMRF-35-H9; CMRF35-H9; CMRF35-H; IGSF12; IRp60; CLM-8; IRC1; IRC1/IRC2; IRC2; CD300a molecule; CD300a; CLM8; CMRF35HIRp60; LMIR1; MAIR-I; Mcipr1; NKRL; Pigr4

Purity :

Greater than 95% as determined by Tris-Bis PAGE.

Buffer :

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage