protein

Corneodesmosin/CDSN Protein, Human (HEK293, His)

HY-P7820

10 μg;50 μg

80;240 USD

Corneodesmosin/CDSN Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

80;240 USD

PSORS1C1/CDSN, a keratin protein present in cornified desmosomes, is involved in the repair of human epidermis and other keratinized squamous epithelium. The expression of PSORS1C1/CDSN is associated with immune skin diseases such as psoriasis, and Cdsn deficiency causes skin barrier damage. Corneodesmosin/CDSN Protein, Human (HEK293, His) is the recombinant human-derived Corneodesmosin/CDSN protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Corneodesmosin/CDSN Protein, Human (HEK293, His) is 496 a.a., with molecular weight of 58-70 kDa.

Human

PSORS1C1/CDSN is a corneodesmosin found in corneodesmosomes, which are localized in human epidermis and other keratinized squamous epithelium. PSORS1C1/CDSN is encoded by CDSN and primarily contributes to susceptibility to psoriasis, an immunodermatological disease. CDSN is polymorphic in the human population and is associated with ankylosing spondylitis (AS), psoriasis, hypotrichosis, and desquamation syndrome. Pediatric dermatosis, in particular, is caused by an autosomal recessive biallelic mutation in CDSN. In epidermal-specific Cdsn-deficient mouse models, epidermal barrier disruption occurs and epidermal cytokine production is increased.

rHuCorneodesmosin/CDSN, His; Corneodesmosin; S Protein; CDSN

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.