protein

PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P78194

20 μg;50 μg

270;510 USD

PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg;50 μg

270;510 USD

PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Human

The receptor described in the text is the platelet-derived growth factor receptor alpha (PDGFRA). PDGFRA is involved in various cellular processes, including embryonic development, cell proliferation, survival, differentiation, chemotaxis, migration, and blood vessel development. It plays a crucial role in the recruitment of pericytes and smooth muscle cells to endothelial cells, as well as in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. PDGFRA is required for normal development of the cardiovascular system and for the formation of a branched network of capillaries in kidney glomeruli. It promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its ligands, including homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB, or homodimeric PDGFD, leads to the activation of several signaling cascades. PDGFRA phosphorylates various downstream effectors, including PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1, NCK1, PDCD6IP/ALIX, and STAM. The receptor signaling is regulated by protein phosphatases that dephosphorylate the receptor and its downstream effectors, as well as by the rapid internalization of the activated receptor.

JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.