protein

TGF beta 1/TGFB1 LAP Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P78168

20 μg;50 μg

215;450 USD

TGF beta 1/TGFB1 LAP Protein, Human (Biotinylated, HEK293, His-Avi)

Protein

HEK293

20 μg;50 μg

215;450 USD

The latency-associated peptide (LAP) of the transforming growth factor β-1 (TGF-β-1) proprotein is an important precursor that forms a complex with TGF-β-1. LAP maintains the latent state of TGF-β-1 during storage in the extracellular matrix, ensuring controlled activation. Interactions with “environmental molecules” such as LTBP1, LRRC32/GARP, and LRRC33/NRROS intricately regulate TGF-β-1 activation. LRRC33/NRROS influences the activation of macrophages and microglia, while LRRC32/GARP controls the activation of activated regulatory T cells. Interactions with integrins induce conformational changes in LAP, releasing active TGF-β-1. LAP orchestrates controlled TGF-β-1 activation in different physiological contexts. Recombinant human TGF beta 1/TGFB1 LAP (biotinylated, expressed in HEK293 cells, Avi-tagged) is a biotinylated, Avi-tagged LAP protein expressed in HEK293 cells.