protein

IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P78154

20 μg;50 μg

245;540 USD

IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg;50 μg

245;540 USD

IL-15R alpha is a high affinity receptor for IL-15 (K d : 100 pM) [1] . IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells [2] . IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development [3] . IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human extracellular region of IL-15R alpha (I31-T205) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.

Human

IL-15R alpha is expressed on various cell types, including lymphocytes, myeloid cells, nonlymphoid and nonhematopoietic cells [4] . IL-15R alpha is down-regulated in Epstein-Barr virus associated gastric cancer (EBVaGC) via promoter hypermethylation [5] . The sequence of amino acids in IL-15R alpha differs in different species. Human IL-15R alpha shares IL-15R alpha is required for transporting of IL-15 from the endoplasmic reticulum to the cell surface to bind with β (CD122) and γ (CD132) chains on responding lymphocytes [4] [6] . When binding with IL-15, the complex increases the in vivo half-life of IL-15 and enhances binding affinity of IL-15 with IL-15Rβ/γ in NK cells and CD8+ T cells. Thus, the signal transmission improves proliferation and antitumor activities of NK cells and CD8+ T cells [2] . Moreover, IL-15R alpha on the cancer cell surface induces the malignant phenotype, such as augmented cancer cell growth, migration and invasion, and decreased apoptosis [5] . IL-15R alpha binds with IL-15 and activates the antitumor functions of NK cells and CD8+ T cells, and is also important in memory CD8 T cell homeostasis and lymphocyte development [2] [3] .

IL-15 R alpha; CD215; IL-15RA; MGC104179

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.