protein

KRAS Protein, Human (G12V, His)

HY-P7805

10 μg;50 μg

55;150 USD

KRAS Protein, Human (G12V, His)

proteins

E. coli

10 μg;50 μg

55;150 USD

KRAS protein is a key Ras family member that binds GDP/GTP and has intrinsic GTPase activity. Its critical role in regulating cell proliferation emphasizes its importance in cellular processes. KRAS Protein, Human (G12V, His) is the recombinant human-derived KRAS protein, expressed by E. coli , with N-6*His labeled tag and G12V, , , , mutation. The total length of KRAS Protein, Human (G12V, His) is 184 a.a., with molecular weight of 25-30 kDa, observed by reducing SDS-PAGE.

Human

KRAS, a pivotal member of the Ras protein family, exhibits the ability to bind GDP/GTP and possesses intrinsic GTPase activity. Its crucial involvement in the regulation of cell proliferation underscores its significance in cellular processes. Notably, KRAS plays a prominent role in promoting oncogenic events, particularly in colorectal cancer (CRC), where it induces transcriptional silencing of tumor suppressor genes (TSGs) in a ZNF304-dependent manner. This multifaceted functionality highlights KRAS as a key player in cellular dynamics and emphasizes its relevance in both normal and pathological cellular processes.

Ki-Ras; c-K-ras; KRAS2; RASK2; KRAS4B; KRAS4B; K-Ras4B

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.