protein

VLDLR Protein, Mouse (HEK293, His)

HY-P78049

20 μg;50 μg;100 μg

150;290;450 USD

VLDLR Protein, Mouse (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

150;290;450 USD

VLDLR protein is a multifunctional cell surface receptor that plays a crucial role in energy metabolism by binding VLDL and promoting cellular uptake through endocytosis.In addition to lipid transport, VLDLR has broad binding affinities for molecules such as Reelin/RELN, APOE, and CLU.VLDLR Protein, Mouse (HEK293, His) is the recombinant mouse-derived VLDLR protein, expressed by HEK293 , with C-His labeled tag.

Mouse

The VLDLR protein operates as a multifunctional cell surface receptor pivotal in energy metabolism, particularly by binding VLDL and facilitating its cellular uptake through endocytosis. Beyond its role in lipid transport, VLDLR exhibits a broad binding affinity for various molecules, including Reelin/RELN, apolipoprotein E/APOE-containing ligands, and clusterin/CLU. In the inactive state of the pathway, VLDLR forms homo or heterooligomers with LRP8. Upon ligand binding, these homooligomers rearrange into higher-order receptor clusters, transducing the extracellular RELN signal to intracellular signaling processes through DAB1 binding on its cytoplasmic tail. This interaction triggers DAB1 phosphorylation, orchestrating the cell responses crucial for the correct positioning of newly generated neurons. Additionally, VLDLR serves as a stop signal for migrating neurons, preventing entry into the marginal zone. Interactions with various proteins, including LDLRAP1, SNX17, PCSK9, PAFAH1B3, PAFAH1B2, STX5, and CLU, further highlight the intricate regulatory network of VLDLR in cellular processes.

VLDL-R; VLDLR; RP11-320E16.1; CHRMQ1; FLJ35024; VLDLRCH

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.