protein

Semaphorin-7A/SEMA7A Protein, Mouse (HEK293, His)

HY-P78035

20 μg;50 μg

180;355 USD

Semaphorin-7A/SEMA7A Protein, Mouse (HEK293, His)

proteins

HEK293

20 μg;50 μg

180;355 USD

Semaphorin-7A/SEMA7A proteins critically regulate integrin-mediated signaling, affecting cell migration and immune responses.It promotes focal adhesion complex formation, activates PTK2/FAK1, and leads to the phosphorylation of MAPK1 and MAPK3.Semaphorin-7A/SEMA7A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Semaphorin-7A/SEMA7A protein, expressed by HEK293 , with C-His labeled tag.

Mouse

The Semaphorin-7A/SEMA7A protein plays a crucial role in integrin-mediated signaling, contributing to the regulation of cell migration and immune responses. It facilitates the formation of focal adhesion complexes and activates the protein kinase PTK2/FAK1, leading to the subsequent phosphorylation of MAPK1 and MAPK3. Moreover, it enhances the production of pro-inflammatory cytokines by monocytes and macrophages. This protein also plays a significant role in modulating inflammation and T-cell-mediated immune responses. Additionally, it promotes axon growth in the embryonic olfactory bulb and aids in the attachment, spreading, and dendrite outgrowth in melanocytes. It interacts with PLXNC1 and the integrins ITGA1 and ITGB1.

Semaphorin-7A; Semaphorin-K1; Semaphorin-L; Sema L; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH; MGC126692; Sema7A; SEMAK1; SEMAL

Greater than 95% as determined by Tris-Bis PAGE.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice