protein

Semaphorin-7A/SEMA7A Protein, Human (HEK293, His)

HY-P78033

5 μg;10 μg;50 μg;100 μg

62;105;294;500 USD

Semaphorin-7A/SEMA7A Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

62;105;294;500 USD

Semaphorin-7A (SEMA7A) plays a key role in integrin-mediated signaling, affecting multiple cellular functions, including cell migration and immune responses. SEMA7A promotes focal adhesion complex formation, activates PTK2/FAK1 and induces phosphorylation of MAPK1 and MAPK3. Semaphorin-7A/SEMA7A Protein, Human (HEK293, His) is the recombinant human-derived Semaphorin-7A/SEMA7A protein, expressed by HEK293 , with C-8*His labeled tag.

Human

The Semaphorin-7A (SEMA7A) protein assumes a crucial role in integrin-mediated signaling, exerting its influence on diverse cellular functions that include the regulation of cell migration and immune responses. SEMA7A actively promotes the formation of focal adhesion complexes, activating protein kinase PTK2/FAK1 and subsequently inducing the phosphorylation of MAPK1 and MAPK3. Furthermore, it plays a significant role in orchestrating the production of pro-inflammatory cytokines by monocytes and macrophages, thereby modulating inflammation and T-cell-mediated immune responses. In developmental contexts, SEMA7A is implicated in promoting axon growth in the embryonic olfactory bulb and facilitates attachment, spreading, and dendrite outgrowth in melanocytes. Its intricate molecular interactions involve associations with integrins ITGA1 and ITGB1, suggesting its involvement in mediating cell adhesion, and it interacts with PLXNC1, adding to the complexity of its regulatory role in diverse cellular processes.

Semaphorin-7A; Semaphorin-K1; Semaphorin-L; Sema L; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH; MGC126692; Sema7A; SEMAK1; SEMAL

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.