protein

RNF43 Protein, Mouse (HEK293, Fc)

HY-P78030

20 μg;50 μg;100 μg

140;270;430 USD

RNF43 Protein, Mouse (HEK293, Fc)

proteins

HEK293

20 μg;50 μg;100 μg

140;270;430 USD

RNF43 Protein, a receptor tyrosine kinase, regulates the Wnt signaling pathway by promoting the degradation of Frizzled receptors. It plays a crucial role in embryonic development and tissue homeostasis. Dysregulation of RNF43 Protein is associated with various cancers, making it a potential therapeutic target in cancer treatment. RNF43 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived RNF43 protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

RNF43 is an E3 ubiquitin-protein ligase with a pivotal role as a negative regulator in the Wnt signaling pathway. It functions by facilitating the ubiquitination, endocytosis, and subsequent degradation of components in the Wnt receptor complex, specifically targeting Frizzled. Its regulatory influence extends to both canonical and non-canonical Wnt signaling pathways, as demonstrated in various studies. Additionally, in conjunction with RSPO2 and ZNRF3, RNF43 forms a crucial regulatory triad, serving as a master switch that governs limb specification. This underscores the significance of RNF43 in orchestrating key developmental processes and fine-tuning Wnt signaling for proper cellular functions.

E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43; Rnf43

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.