protein

PLD4 Protein, Human (HEK293, His)

HY-P78019

5 μg;10 μg;20 μg;50 μg

95;145;215;355 USD

PLD4 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg

95;145;215;355 USD

PLD4 Protein, a phospholipase, plays a crucial role in immune responses and inflammation. Dysregulation of PLD4 Protein has been associated with autoimmune disorders and inflammatory diseases. Targeting PLD4 Protein may provide potential therapeutic interventions in these conditions by modulating immune responses, suppressing inflammation, and managing related disorders. PLD4 Protein, Human (HEK293, His) is the recombinant human-derived PLD4 protein, expressed by HEK293 , with C-His labeled tag. The total length of PLD4 Protein, Human (HEK293, His) is 455 a.a., with molecular weight of 68-75 kDa.

Human

PLD4 Protein, a 5'->3' DNA exonuclease, is responsible for digesting single-stranded DNA (ssDNA). Its role extends to regulating inflammatory cytokine responses by degrading nucleic acids, thereby decreasing the concentration of ssDNA capable of stimulating TLR9, a nucleotide-sensing receptor. Additionally, PLD4 Protein is involved in the phagocytosis of activated microglia.

5'-3' exonuclease PLD4; Choline phosphatase 4; Phospholipase D4; PLD 4

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of 50 mM MES, 100 mM NaCl, pH 6.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.