protein

Notch3 Protein, Human (HEK293, Fc)

HY-P78009

20 μg;50 μg

110;210 USD

Notch3 Protein, Human (HEK293, Fc)

proteins

HEK293

20 μg;50 μg

110;210 USD

Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch3 Protein, Human (HEK293, Fc) is the recombinant human-derived Notch3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Notch3 Protein, Human (HEK293, Fc) is 428 a.a., with molecular weight of 75-83 kDa.

Human

Notch 3 protein serves as a receptor for membrane-bound ligands, including Jagged1, Jagged2, and Delta1, playing a pivotal role in regulating cell-fate determination. Upon ligand activation, the released notch intracellular domain (NICD) forms a transcriptional activator complex with RBPJ/RBPSUH, initiating the activation of genes within the enhancer of split locus. This multifaceted protein influences cellular differentiation, proliferation, and apoptotic programs. Structurally, it exists as a heterodimer composed of a C-terminal fragment (N(TM)) and a N-terminal fragment (N(EC)), likely linked by disulfide bonds. Notch 3 interacts with transcriptional coactivators MAML1, MAML2, and MAML3, modulating downstream transcriptional processes. It also engages with PSMA1 and HIF1AN, contributing to diverse cellular functions and regulatory pathways.

CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.