protein

LOX-1/OLR1 Protein, Mouse (HEK293, His)

HY-P77986

20 μg;50 μg

186;410 USD

LOX-1/OLR1 Protein, Mouse (HEK293, His)

proteins

HEK293

20 μg;50 μg

186;410 USD

The LOX-1/OLR1 protein is a receptor on vascular endothelial cells that promotes the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL). This process is indicative of atherosclerosis and triggers endothelial cell activation, pro-inflammatory responses, oxidative conditions, and apoptosis. LOX-1/OLR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LOX-1/OLR1 protein, expressed by HEK293 , with N-His labeled tag. The total length of LOX-1/OLR1 Protein, Mouse (HEK293, His) is 304 a.a., with molecular weight of 55-63 kDa.

Mouse

LOX-1/OLR1 serves as a crucial receptor in the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. The binding of oxLDL to LOX-1 triggers vascular endothelial cell activation and dysfunction, leading to pro-inflammatory responses, increased oxidative conditions, and apoptosis. This interaction induces the activation of NF-kappa-B, contributing to intracellular reactive oxygen species production and fostering various pro-atherogenic cellular responses, including reduced nitric oxide release, monocyte adhesion, and apoptosis. Beyond its role in atherosclerosis, LOX-1 acts as a receptor for HSP70, participating in antigen cross-presentation to naive T-cells in dendritic cells. Furthermore, it plays a pivotal role in inflammatory processes by functioning as a leukocyte-adhesion molecule at the vascular interface during endotoxin-induced inflammation. Additionally, LOX-1 acts as a receptor for advanced glycation end products, activated platelets, monocytes, apoptotic cells, and both Gram-negative and Gram-positive bacteria. The receptor exists as a homodimer, potentially forming hexamers composed of three homodimers, and interacts with HSP70.

Ox-LDL receptor 1; LOX-1; CLEC8A; LOX1; OLR1; LOXIN; SR-E1; SCARE1; SLOX1

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.