protein

Klotho beta Protein, Human (HEK293, His)

HY-P77972

5 μg;10 μg;20 μg;50 μg;100 μg

135;228;389;855;1450 USD

Klotho beta Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg;100 μg

135;228;389;855;1450 USD

Klotho beta protein plays a critical role in the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), a key enzyme controlling bile acid synthesis. Although its glycosidase activity may be inactive, Klotho beta enhances the binding ability of FGFR1 and FGFR4 to FGF21, promoting their interaction. Klotho beta Protein, Human (HEK293, His) is the recombinant human-derived Klotho beta protein, expressed by HEK293 , with C-His labeled tag. The total length of Klotho beta Protein, Human (HEK293, His) is 954 a.a., with molecular weight of 112-140 kDa.

Human

The Klotho beta protein plays a significant role in transcriptional regulation by contributing to the repression of cholesterol 7-alpha-hydroxylase (CYP7A1), a key enzyme in bile acid synthesis. While likely inactive as a glycosidase, Klotho beta enhances the binding ability of FGFR1 and FGFR4 to FGF21, indicating its involvement in fibroblast growth factor (FGF) signaling. The protein directly interacts with both FGF19 and FGF21, underscoring its association with crucial components of the FGF pathway. These interactions, particularly with FGF21, suggest a potential role in metabolic regulation and highlight Klotho beta's involvement in modulating cellular responses and metabolic pathways (

betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; MGC142213

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.