protein

IL-20R alpha Protein, Mouse (HEK293, Fc)

HY-P77965

20 μg;50 μg

140;310 USD

IL-20R alpha Protein, Mouse (HEK293, Fc)

proteins

HEK293

20 μg;50 μg

140;310 USD

IL-20R alpha Protein (IL20RA) is the alpha subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway [1] . The IL20RA/IL20RB dimer is a receptor for IL-19, IL-20 and IL-24, while the IL20RA/IL10RB dimer is a receptor for IL-26 [3] . IL-20R alpha Protein is consists of 553 amino acids (M1-N553) with a transmembrane domain (254-274 a.a.). IL-20R alpha Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal His-tag.

Mouse

IL-20R alpha, also known as a alpha subunit of IL-20 receptor (IL-20RA), belongs to the type II cytokine receptor family [1] . IL-20R alpha is widely expressed with highest levels in skin and testis and high levels in brain [2] . IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes [3] . IL-20R alpha forms functional heterodimers with different subunit protein. IL-20R alpha serves as the receptor for IL-19, IL-20 and IL-24 by dimerizing with IL20RB, however serves as the receptor for IL-26 by dimerizing with IL-10RB. IL-20R alpha transduces ligand-binding at least in part through STAT3 activation, and plays an important role in epidermal function and psoriasis [4] . The sequence of amino acids in IL-12 beta proteins of mouse is very different from human (64.64%).

IL-20R-alpha; IL-20RA; CRF2-8; IL-20R1; ZcytoR7; FLJ40993

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.