protein

TMEM219/IGFBP-3R Protein, Human (HEK293, Fc)

HY-P77962

20 μg;50 μg

175;385 USD

TMEM219/IGFBP-3R Protein, Human (HEK293, Fc)

proteins

HEK293

20 μg;50 μg

175;385 USD

The TMEM219/IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This protein actively binds to IGFBP3, forming a key molecular interaction that may initiate the apoptosis signaling pathway. TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is the recombinant human-derived TMEM219/IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is 166 a.a., with molecular weight of 60-70 kDa.

Human

TMEM219, also known as IGFBP-3R, serves as a cell death receptor with specificity for insulin-like growth factor binding protein 3 (IGFBP3). This receptor is implicated in potentially mediating caspase-8-dependent apoptosis upon binding with its ligand, IGFBP3. The direct interaction between TMEM219 and IGFBP3 underscores its role in transducing signals related to cell survival and death pathways. Additionally, TMEM219 interacts with caspase-8, further suggesting its involvement in regulating apoptotic processes, potentially through the caspase-8-dependent pathway.

IGFBP-3R; GFBP3R; LOC124446; TMEM219

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.