protein

HGFA/HGF Activator Protein, Mouse (HEK293, His)

HY-P77960

2 μg;10 μg;20 μg;50 μg;100 μg

42;116;180;360;485 USD

HGFA/HGF Activator Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;10 μg;20 μg;50 μg;100 μg

42;116;180;360;485 USD

HGFA/HGF activating proteins activate HGF by converting HGF into its heterodimeric form, which is critical for cell growth, development, and tissue repair. It induces cellular responses such as proliferation, migration, and differentiation. HGFA/HGF Activator Protein, Mouse (HEK293, His) is the recombinant mouse-derived HGFA/HGF Activator protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HGFA/HGF Activator Protein, Mouse (HEK293, His) is 619 a.a., with molecular weight of approximately 107.5 kDa.

Mouse

HGFA/HGF Activator Protein is responsible for activating hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. This heterodimer consists of a short chain and a long chain that are linked together by a disulfide bond. HGFA/HGF Activator Protein plays a crucial role in various biological processes, including cell growth, development, and tissue repair. Its activation of HGF leads to the induction of cellular responses such as cell proliferation, migration, and differentiation. By modulating HGF activity, HGFA/HGF Activator Protein contributes to the regulation of cell-matrix adhesion, cell-cell adhesion, and cell morphology. It interacts with various proteins, including THSD1, PTK2/FAK1, TLN1, and VCL, and its association with CTNNA1 is essential for its localization to cell-cell junctions and the regulation of E-cadherin expression. Moreover, HGFA/HGF Activator Protein forms a complex with APBB1IP, NRAP, TLN1, CTNNB1, SYNM, SORBS1, and CTNNA1, and it triggers conformational changes when binding to ACTN4. Its multifaceted interactions and activities highlight its importance in cellular processes and underline its potential therapeutic applications.

HGF activator; HGFA; Hgfac; MGC138395; MGC138397

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris,150 mM NaCl, 2 mM CaCl 2 , pH 8.0 or 20 mM PB, 150 mM NaCl, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.