protein

CD42a/GP9 Protein, Human (HEK293, Fc)

HY-P77953

20 μg;50 μg;100 μg

180;345;550 USD

CD42a/GP9 Protein, Human (HEK293, Fc)

proteins

HEK293

20 μg;50 μg;100 μg

180;345;550 USD

CD42a/GP9 protein, forming the GPIb-V-IX complex, acts as the von Willebrand factor (vWF) receptor, facilitating vWF-dependent platelet adhesion to blood vessels—a crucial step in arterial hemostasis. The GP-IX component contributes to the membrane insertion and orientation of GP-Ib, forming a non-covalent linkage with the GP-Ib heterodimer composed of two GP-Ib beta subunits and one GP-Ib alpha subunit. CD42a/GP9 Protein, Human (HEK293, Fc) is the recombinant human-derived CD42a/GP9 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD42a/GP9 Protein, Human (HEK293, Fc) is 131 a.a., with molecular weight of 48-52 kDa.

Human

The CD42a/GP9 protein, also known as the GPIb-V-IX complex, plays a pivotal role as the von Willebrand factor (vWF) receptor, facilitating vWF-dependent platelet adhesion to blood vessels. This interaction is a crucial initial step in hemostasis, especially in response to injuries in the arterial circulation. GP-IX, within the GPIb-V-IX complex, is involved in the membrane insertion and orientation of GP-Ib. Notably, two GP-Ib beta subunits are disulfide-linked to one GP-Ib alpha subunit, and the GP-IX component forms a non-covalent linkage with the GP-Ib heterodimer.

GP-IX; GPIX; Glycoprotein 9; CD42a; GP9; CD42a

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 250 mM NaCl, pH 8.5. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.