protein

CD42b/GP1BA Protein, Human (HEK293, His)

HY-P77951

20 μg;50 μg

240;400 USD

CD42b/GP1BA Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg

240;400 USD

CD42b/GP1BA protein is an important platelet membrane protein that interacts with the A1 domain of von Willebrand factor and contributes to the formation of subendothelial platelet plugs. Its GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively called GP-Ib. CD42b/GP1BA Protein, Human (HEK293, His) is the recombinant human-derived CD42b/GP1BA protein, expressed by HEK293 , with C-His labeled tag.

Human

CD42b/GP1BA, a crucial surface membrane protein on platelets, plays a pivotal role in the formation of platelet plugs by engaging with the A1 domain of von Willebrand factor (vWF), which is already bound to the subendothelium. The GP1BA subunit forms a disulfide-linked complex with two GP1BB subunits, collectively known as GP-Ib. The GP-IX subunit is intricately associated with the GP-Ib heterodimer through a non-covalent linkage. Notably, CD42b/GP1BA interacts with filamin B (FLNB), and FLNA through specific filamin repeats, establishing essential connections that contribute to the intricate regulation of platelet function and hemostasis.

GP-Ib alpha; GPIb-alpha; GPIbA; GP1BA; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; VWDP; BP1BA; MGC34595

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.