protein

GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P77944

20 μg;50 μg

235;510 USD

GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg;50 μg

235;510 USD

GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi) is 407 a.a., with molecular weight of 55-65 kDa.

Human

GUCY2C, a guanylyl cyclase, serves as a catalyst in the synthesis of cyclic (cGMP) from GTP, as evidenced by studies. Additionally, this protein functions as a receptor for the E. coli heat-stable enterotoxin, where the enterotoxin significantly stimulates the accumulation of cin mammalian cells expressing GUCY2C. Furthermore, GUCY2C is activated by endogenous peptides, guanylin and uroguanylin. This multifaceted role underscores the intricate regulatory mechanisms involving GUCY2C in cellular signaling and its responsiveness to various stimuli.

Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.