protein

FOLR2 Protein, Mouse (HEK293, His)

HY-P77937

20 μg;50 μg

85;170 USD

FOLR2 Protein, Mouse (HEK293, His)

proteins

HEK293

20 μg;50 μg

85;170 USD

FOLR2 Protein, crucial for binding folate and its derivatives, facilitates their transport into cells with notable affinity under neutral pH. Upon endocytosis and exposure to slightly acidic pH, FOLR2 undergoes a conformational change, significantly reducing its affinity for folates and releasing them from the receptor, similar to other proteins. FOLR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR2 Protein, Mouse (HEK293, His) is 207 a.a., with molecular weight of 30-40 kDa.

Mouse

The FOLR2 protein plays a pivotal role in binding to folate and reduced folic acid derivatives, facilitating the transport of 5-methyltetrahydrofolate and folate analogs into the intracellular space. It exhibits a remarkable affinity for folate and folic acid analogs under neutral pH conditions. However, upon receptor endocytosis, exposure to a slightly acidic pH induces a conformational change in FOLR2, leading to a substantial reduction in its affinity for folates and subsequent release from the receptor, as observed in similar proteins.

FBP; FOLR2; OLR2; BETA-HFR; FR-BETA; FR-P3

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.