protein

ENPP-1 Protein, Human (HEK293, His)

HY-P77923

20 μg;50 μg;100 μg

230;450;720 USD

ENPP-1 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

230;450;720 USD

ENPP-1 protein is a nucleotide pyrophosphatase that inhibits excessive hydroxyapatite crystal growth by preferentially hydrolyzing ATP and other nucleoside triphosphates to generate PPi, thereby critically regulating bone mineralization and soft tissue calcification. ENPP-1 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ENPP-1 Protein, Human (HEK293, His) is 828 a.a., with molecular weight of 110-120 kDa.

Human

ENPP-1 Protein, a nucleotide pyrophosphatase, plays a crucial role in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. By preferentially hydrolyzing ATP and other nucleoside 5' triphosphates, such as GTP, CTP, and UTP, ENPP-1 generates diphosphate (PPi), which inhibits the further growth of nascent hydroxyapatite crystals, thereby preventing excessive bone mineralization and calcification of soft tissues. Additionally, it participates in the hydrolysis of diadenosine polyphosphates and 3',5'-cAMP to AMP, and may regulate nucleotide sugar availability in the endoplasmic reticulum and Golgi, influencing purinergic signaling. ENPP-1 also contributes to the repression of hedgehog signaling, inhibiting ectopic joint calcification and maintaining articular chondrocytes. Furthermore, it is implicated in modulating insulin sensitivity and function, participating in melanogenesis, and can hydrolyze 2',3'-cGAMP, a second messenger involved in triggering type-I interferon production. The exact role of 2',3'-cGAMP hydrolysis in the extracellular space remains unclear.

E-NPP 1; NPPase; ENPP1; NPPS; PC1; PDNP1; Ly-41 Antigen; M6S1; M6S1NPP1; NPP1; PCA1; PCA1ARHR2

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.