CLEC12A/MICL Protein, Cynomolgus (HEK293, His) | MedChem Express LLC HY-P77903 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

CLEC12A/MICL Protein, Cynomolgus (HEK293, His)

catalog :

HY-P77903

quantity :

20 μg;50 μg

price :

170;325 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P77903

Product Name :

CLEC12A/MICL Protein, Cynomolgus (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

20 μg;50 μg

List Price :

170;325 USD

Product Description :

CLEC12A/MICL Protein is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is 201 a.a., with molecular weight of 38-60 kDa.

SpeciesSummary :

Cynomolgus

Background :

C-type lectin domain family 12 member A (CLEC12A) is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a type II transmembrane protein expressed in humans by myeloid cells, including neutrophils, monocytes, plasmacytoid BDCA2 + , and myeloid CD1 + c/CD19 - dendritic cells. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. In addition, CLEC12A may regulate the inflammatory response to infectious agents through direct interaction with pathogen-derived crystals or antigens. It regulates cytokine synthesis by synergizing or antagonizing signaling pathways of a variety of receptors including TLRs and the CD40 receptor in a stimulus-dependent manner. CLEC12A is also involved in adaptive immunity through its ability to internalize antigen for routing to Major Histocompatibility complex (MHC) compartments and presentation to T cells [1] [2] .

ALTnames :

MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2

Purity :

Greater than 95% as determined by Tris-Bis PAGE.

Buffer :

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage