protein

Apolipoprotein A-V/APOA5 Protein, Mouse (His)

HY-P77872

20 μg;50 μg

170;375 USD

Apolipoprotein A-V/APOA5 Protein, Mouse (His)

proteins

E. coli

20 μg;50 μg

170;375 USD

Apolipoprotein AV (APOA5) is primarily associated with HDL and VLDL, affecting triglyceride (TG) levels. APOA5 stimulates apo-CII lipoprotein lipase (LPL) TG hydrolysis and inhibits hepatic VLDL-TG production without affecting VLDL-apoB production. Apolipoprotein A-V/APOA5 Protein, Mouse (His) is the recombinant mouse-derived Apolipoprotein A-V/APOA5 protein, expressed by E. coli , with N-His labeled tag. The total length of Apolipoprotein A-V/APOA5 Protein, Mouse (His) is 348 a.a., with molecular weight of ~40.5 kDa.

Mouse

Apolipoprotein A-V (APOA5) is a minor apolipoprotein primarily associated with HDL and, to a lesser extent, with VLDL, and may also be linked to chylomicrons. It plays a crucial role in regulating plasma triglyceride (TG) levels, acting as a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and as an inhibitor of the hepatic VLDL-TG production rate, without affecting the VLDL-apoB production rate. APOA5 activates lecithin:cholesterol acyltransferase (LCAT) poorly and does not enhance cholesterol efflux from macrophages. Additionally, it exhibits binding affinity for heparin and interacts with GPIHBP1. Furthermore, APOA5 engages in an interaction with SORL1, influencing its internalization and sorting, either to lysosomes for degradation or to the trans-Golgi network.

Apolipoprotein A-V; Apo-AV; ApoA-V; Apolipoprotein A5; Apoa5; Rap3

Greater than 95% as determined by Tris-Bis PAGE.

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, 2 mM DTT, pH 8.5.

Shipping with dry ice