protein

Tissue Factor Protein, Human (HEK293, His)

HY-P7787

10 μg;50 μg

150;420 USD

Tissue Factor Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

150;420 USD

Tissue Factor Protein, Human (HEK293, His) is a recombinant human CD142 expressed in HEK 293 cells with a His tag at the C-terminus. Coagulation Factor III/CD142 Protein is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process [1] [2] .

Human

Tissue factor (TF), also known as CD142, a 47-kDa transmembrane glycoprotein, is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process. TF is the only membrane-bound coagulation factor (factor III), cofactor, and surface receptor for coagulation factor VII (fVII)/activated fVII (fVIIa). TF is commonly yet selectively expressed by multiple tumor compartments, including but not limited to, the cancer cells, cancer stem cells and tumor vascular endothelial cells, whereas it is negatively, minimally or restrictedly expressed in normal cells. TF regulates tumour growth, embryonic and oncogenic blood vessel formation, inflammation and sepsis [1] [2] .

rHuCD142, His; Tissue Factor; TF; Coagulation Factor III; Thromboplastin; CD142; F3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM Tris, 150 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.