protein

Semaphorin-4D/SEMA4D Protein, Cynomolgus (HEK293, His)

HY-P77832

20 μg;50 μg

80;175 USD

Semaphorin-4D/SEMA4D Protein, Cynomolgus (HEK293, His)

proteins

HEK293

20 μg;50 μg

80;175 USD

Semaphorin-4D/SEMA4D is the cell surface receptor for PLXNB1 and PLXNB2 and plays a crucial role in intercellular signaling. It regulates GABAergic synapse development and promotes inhibitory synapses in a PLXNB1-dependent manner. Semaphorin-4D/SEMA4D Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Semaphorin-4D/SEMA4D protein, expressed by HEK293 , with C-His labeled tag. The total length of Semaphorin-4D/SEMA4D Protein, Cynomolgus (HEK293, His) is 711 a.a., with molecular weight of 90-120 kDa.

Cynomolgus

Semaphorin-4D (SEMA4D) operates as a cell surface receptor for PLXNB1 and PLXNB2, assuming a crucial role in cell-cell signaling. This versatile protein is implicated in diverse cellular processes, including the regulation of GABAergic synapse development, where it fosters the development of inhibitory synapses in a PLXNB1-dependent manner. In hippocampal neurons, SEMA4D influences the complexity and arborization of developing neurites by activating PLXNB1, thereby mediating RHOA activation. Additionally, SEMA4D is involved in promoting the migration of cerebellar granule cells and induces B-cell aggregation, enhancing their viability in vitro. Furthermore, SEMA4D stimulates endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway. Operating as a homodimer, SEMA4D interacts with both PLXNB1 and PLXNB2, underscoring its intricate involvement in various cellular and developmental processes.

Semaphorin-4D; CD100; SEMA4D; C9orf164; FLJ33485; FLJ34282; FLJ39737; FLJ46484; M-sema-G; MGC169138; MGC169141; SEMAJ; coll-4

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.